Chromosomal Microarray: Fast & Precise High-Resolution CMA Test
Clinical Overview & Diagnostic Indications
First of all, Chromosomal Microarray (CMA) is the gold-standard molecular cytogenetic test recommended for detecting submicroscopic chromosomal gains and losses. Essentially, using high-density Single Nucleotide Polymorphism (SNP) array technology across 750,000+ probes, CMA evaluates copy number variations (CNVs), microdeletions, microduplications, and loss of heterozygosity down to 10 kilobases with 99.9% precision.
Furthermore, book your Single Nucleotide Polymorphism Array (SNP Array) at Henotic Diagnostics for authoritative diagnostic clarity. In addition, our accredited genomic laboratory operates 24/7 with convenient home sample collection services.
📋 Your Chromosomal Microarray at a Glance
| 🔍 Detail | 📋 Info |
|---|---|
| 🩺 Technology | CMA 750k SNP Array (aCGH + SNP Microarray) |
| 🩸 Sample Type | Peripheral Blood / Amniotic Fluid / CVS / POC |
| 💰 Price Range | ₹12,000 – ₹22,000 (All-inclusive diagnostic fee) |
| 📄 Report TAT | 7 to 10 Days (Includes ClinVar CNV interpretation) |
| 🕐 Availability | 24/7 Operations (Home sample collection available) |
| 👩⚕️ Specialist | Dr. Pratibha Patil — Chief Consultant Radiologist |
| 🍽️ Fasting | No Fasting Required (Normal diet maintained) |
| 💳 Insurance | Reimbursement Documentation Support provided |
| 🏅 Accreditation | NABL Accredited · ISO Certified · CAP Compliant |
Chromosomal Microarray Quality Standards & Certifications
Chromosomal Microarray Test: Overview
To begin with, Single Nucleotide Polymorphism Array (SNP Array) is an advanced molecular genomic technology designed to scan the entire human genome for chromosomal imbalance. At the same time, experts at Henotic Diagnostics process patient DNA on high-density microfluidic array chips to identify structural microdeletions and microduplications.
Furthermore, comfortable reception lounge providing supportive patient registration for advanced cytogenetic testing
What Does Chromosomal Microarray Evaluate?
Specifically, Single Nucleotide Polymorphism Array (SNP Array) analyzes 23 pairs of human chromosomes for submicroscopic gain or loss of genetic material. Consequently, bioinformatic algorithms detect microdeletion syndromes (e.g. DiGeorge, Williams, Prader-Willi) and microduplications that escape conventional G-banded karyotyping. Furthermore, SNP probes map Absence of Heterozygosity (AOH) linked to uniparental disomy and consanguinity. As a result, pediatricians and obstetricians obtain conclusive genetic diagnoses. In fact, to review chromosomal structure facts, consult the NIH NHGRI Chromosomes Fact Sheet.
Furthermore, Advanced Molecular Cytogenetics providing clear microdeletion and CNV insights.
What is Chromosomal Microarray?
In general, while traditional karyotyping resolves large chromosomal alterations (>5-10 megabases), Single Nucleotide Polymorphism Array (SNP Array) achieves submicroscopic resolution down to 10-50 kilobases (100 times higher resolution). Essentially, patient DNA and reference controls are hybridized onto array chips containing hundreds of thousands of genomic probes. Therefore, automated scanners calculate signal intensity ratios to pinpoint microscopic deletions and duplications. Additionally, to read about copy number variation genetics, examine the Nature Genetics journal.
Additionally, high-resolution SNP microarray scanners analyze 750,000+ probes with 99.9% copy number accuracy
What Does a Chromosomal Microarray Test Detect?
Overall, clinical Single Nucleotide Polymorphism Array (SNP Array) analysis evaluates key genomic abnormality classes:
Key Chromosomal Abnormalities Evaluated by CMA
In addition, cytogenetic bioinformatic software displays log2 copy number ratio shifts and SNP allele peaks
When Is Chromosomal Microarray Recommended?
For example, pediatricians, pediatric neurologists, and obstetricians order Chromosomal Microarray for first-line genetic evaluation. In particular, testing is recommended for children with unexplained developmental delay, intellectual disability, autism spectrum disorder (ASD), and congenital anomalies. Moreover, in prenatal care, CMA is the primary test for fetal structural malformations detected on ultrasound or abnormal NIPT screens. In addition, to review ACMG diagnostic standards, examine the ACMG Medical Genetics guidelines.
Moreover, expert genetic counseling translates microdeletion array findings into personalized clinical management
Clinical Superiority: First-Line CMA vs. Traditional G-Banded Karyotyping
Ideally, pediatricians recommend Chromosomal Microarray (CMA) as the first-tier diagnostic test because conventional karyotyping misses over 80% of pathogenic microdeletions and microduplications. In addition, CMA yields a diagnostic yield of 15-20% compared to only 3% for karyotyping in developmental disorders. Indeed, to review global rare genetic disease facts, consult the WHO Rare Genetic Disease & Health Fact Sheet.
Chromosomal Microarray Cost Guide
| Clinical CMA Service | Approximate Cost (₹) |
|---|---|
| Standard CMA 750k SNP Array Panel | First, standard CMA 750k pricing is ₹12,000 – ₹16,000. |
| High-Density CMA 2.6M Probe Array Panel | Second, ultra-high density CMA 2.6M costs ₹18,000 – ₹22,000. |
| Prenatal Amniotic Fluid / CVS / POC Sample Logistics | In addition, specialized sample handling is complimentary. |
| Clinical Genetic Counseling Consultation | Finally, expert genetic counseling fee is ₹1,000 – ₹1,500. |
Comparison: Chromosomal Microarray (CMA) vs. G-Banded Karyotype vs. WES
On one hand, G-banded karyotyping visualizes whole chromosomes under microscopes, whereas Chromosomal Microarray (CMA) measures submicroscopic copy number variations, and Whole Exome Sequencing (WES) identifies single nucleotide gene mutations. Consequently, selecting the proper genetic test ensures efficient diagnostic resolution. In fact, review the PubMed Clinical Chromosomal Microarray Review.
| Feature | Chromosomal Microarray (CMA) | G-Banded Karyotyping |
|---|---|---|
| Genomic Resolution | First, submicroscopic 10-50 kb resolution. | However, macro-level 5-10 Mb resolution. |
| Diagnostic Yield (Developmental Delay) | Second, high yield of 15% – 20%. | In contrast, low yield of ~3%. |
| Balanced Translocation Detection | In addition, misses balanced translocations. | Meanwhile, detects balanced translocations. |
| Cell Culture Requirement | Finally, no live cell culture needed. | Likewise, requires viable metaphase cells. |
Frequently Asked Questions
What is a Chromosomal Microarray test used for? ▼
Chromosomal Microarray detects chromosomal copy-number changes. Therefore, Henotic Diagnostics may recommend CMA for developmental delay, intellectual disability, congenital anomalies, or selected prenatal findings.
What does CMA detect that karyotyping cannot? ▼
CMA detects many smaller microdeletions and microduplications that standard karyotyping may miss. Therefore, it provides higher-resolution copy-number analysis.
When is prenatal CMA recommended? ▼
Prenatal CMA may be recommended when fetal structural abnormalities are identified or when clinically indicated after genetic counseling. Therefore, the decision should be made with the treating obstetrician or genetics professional.
Can CMA detect single-gene disorders? ▼
Generally, no. CMA primarily detects copy-number changes, whereas single-gene disorders usually require sequencing-based tests such as WES or targeted gene testing.
How long until I receive diagnostic Chromosomal Microarray results? ▼
Fortunately, detailed clinical bioinformatic CMA reports are delivered within 7 to 10 business days.
What is the cost of Chromosomal Microarray? ▼
Overall, high-precision Chromosomal Microarray ranges from ₹12,000 to ₹22,000 all-inclusive.
Quick Appointment Booking
Schedule your Chromosomal Microarray with accredited genomic experts.
Call: 088793 27184 WhatsApp BookingTest Summary
Reporting Clinical Genomic Specialist
Dr. Pratibha Patil
Chief Consultant Radiologist & Clinical Diagnostics Specialist
MBBS, MD (Radiodiagnosis) · 15+ Years Clinical Experience
Furthermore, your Chromosomal Microarray data is evaluated by accredited molecular cytogeneticists and geneticists. Consequently, comprehensive reports empower pediatricians and obstetricians with clear microdeletion and CNV insights.
Our Accreditations & Quality Standards
Certified excellence ensuring SNP microarray precision, bioinformatic CNV interpretation accuracy, and patient privacy.
What Our Patients Say
Real feedback from patients who completed Chromosomal Microarray testing with us.
“Chromosomal Microarray identified a 22q11.2 microdeletion in my son that explaining his developmental delay. Furthermore, targeted therapies were started promptly!”
– Arvind S.
Verified Patient Review“Prompt amniotic fluid CMA testing after an abnormal prenatal scan gave us complete peace of mind. In addition, the genetic consultation was invaluable.”
– Kavita R.
Verified Patient Review“Outstanding NABL accredited molecular cytogenetics lab. Henotic Diagnostics is our premier referral center for pediatric CMA testing.”
– Dr. Sunita K.
Verified Physician ReviewRelevant Diagnostic Cytogenetic & Genomic Services
Corporate Booking Office & Location
If you require Chromosomal Microarray for microdeletion, developmental delay, or prenatal evaluation, do not delay. Call to schedule your sample collection.
Henotic Diagnostics
Second floor, Millennium Empire, Business Park, Plot No 47, D Mart Rd, Sector 15, Kharghar, Navi Mumbai, Panvel, Maharashtra 410210
Phone: 088793 27184 | Hours: Open 24 Hours