Whole Genome Sequencing: Fast & Precise WGS Test
First of all, Whole Genome Sequencing (WGS) is the ultimate genetic diagnostic test, reading all 3 billion base pairs across the entire human genome. Essentially, Next-Generation Sequencing (NGS) profiles both protein-coding exonic regions (~2%) and non-coding intronic regulatory sequences (~98%). As a result, medical geneticists solve uncharacterized genetic conditions that remain invisible on standard exome panels.
Book your WGS Test at Henotic Diagnostics for absolute genomic clarity. Furthermore, our accredited diagnostic facility operates 24/7 to provide seamless sample collection.
📋 Your Whole Genome Sequencing at a Glance
| 🔍 Detail | 📋 Info |
|---|---|
| 🩺 Technology | 30x-60x High-Depth Next-Generation Whole Genome Sequencing |
| 🩸 Sample Type | 3-5 ml Peripheral Blood in EDTA Tube |
| 💰 Price Range | ₹45,000 – ₹75,000 (All-inclusive diagnostic fee) |
| 📄 Report TAT | 21 to 30 Days (Includes ACMG & bioinformatic interpretation) |
| 🕐 Availability | 24/7 Operations (Home sample collection available) |
| 👩⚕️ Specialist | Dr. Pratibha Patil — Chief Consultant Radiologist |
| 🍽️ Fasting | No Fasting Required (Normal diet allowed) |
| 💳 Insurance | Reimbursement Documentation Support provided |
| 🏅 Accreditation | NABL Accredited · ISO Certified · CAP Compliant |
Whole Genome Quality Standards & Certifications
Overview of Whole Genome Sequencing
To begin with, WGS Test (WGS) is the most comprehensive diagnostic tool available in modern genomic medicine. At the same time, experts at Henotic Diagnostics deploy ultra-high-throughput Next-Generation Sequencing to decode your complete 3 billion base pair DNA sequence.
What Does Whole Genome Sequencing Evaluate?
Specifically, WGS evaluates single nucleotide variants (SNVs), copy number variants (CNVs), structural rearrangements, deep intronic splice mutations, promoter region defects, and mitochondrial DNA variants. Consequently, clinical geneticists identify root causes of undiagnosed rare pediatric conditions. Furthermore, high-depth 30x sequencing eliminates blind spots inherent in targeted panels. As a result, physicians formulate tailored therapeutic strategies. In fact, to review clinical research standards, consult the NIH NHGRI WGS Test resource.
Furthermore, comfortable reception lounge ensuring smooth patient intake for genomic sample registration
What is Whole Genome Sequencing?
In general, WGS is an all-inclusive genomic decoding technology. Essentially, while Whole Exome Sequencing reads only the 1-2% of DNA that encodes proteins, WGS reads 100% of the nuclear and mitochondrial DNA. Specifically, powerful bioinformatic supercomputers align billions of short or long reads against human reference genomes. Therefore, variant calling software pinpoints pathogenic mutations hidden deep inside non-coding intronic sequences. Additionally, this single test provides a lifetime genomic baseline.
Additionally, high-throughput NGS platforms process full human genomes at uniform 30x depth
What Does Whole Genome Sequencing Check?
Overall, the test provides complete structural, functional, and non-coding genomic analysis:
Key Genomic Variants & Regions Examined
In addition, bioinformatic software pipelines filter 3 billion base pairs to isolate clinically actionable mutations
When Is Whole Genome Sequencing Recommended?
For example, clinical geneticists and specialists recommend WGS Test for complex medical scenarios. In particular, doctors order WGS for patients with unresolved rare diseases after negative exome sequencing or microarray tests. Moreover, it is recommended for complex neurodevelopmental syndromes, refractory pediatric epilepsy, and rare metabolic disorders. In addition, individuals seeking comprehensive proactive genomic health profiling opt for WGS.
Moreover, expert genetic counseling translates full-genome sequencing reports into personalized medical management
Clinical Advantage of WGS in Unsolved Genetic Odysseys
Ideally, patients should consider WGS if Whole Exome Sequencing (WES) yields negative results despite clear hereditary symptoms. In addition, if non-coding promoter mutations or structural break-points cause disease, WGS is the only test that detects them. Indeed, full genome sequencing provides the ultimate diagnostic clarity.
Whole Genome Sequencing Cost Guide
| Genomic Diagnostic Service | Approximate Cost (₹) |
|---|---|
| Whole Genome Sequencing (30x Clinical Depth) | First, standard WGS test pricing is ₹45,000 – ₹55,000. |
| Ultra-Deep Whole Genome (60x High-Depth WGS) | Second, 60x high-depth WGS costs ₹65,000 – ₹85,000. |
| Trio Whole Exome Sequencing (Proband + Parents) | In addition, Trio WES test costs ₹35,000 – ₹55,000. |
| Post-Test Genetic Counseling Session | Finally, expert genetic consultation fee is ₹1,500 – ₹2,500. |
Comparison: Whole Genome Sequencing vs. Whole Exome Sequencing (WES)
On one hand, Whole Exome Sequencing captures only the 1-2% of coding DNA, whereas WGS Test reads 100% of all 3 billion base pairs including non-coding introns. Consequently, WGS detects structural rearrangements and intronic variants missed by WES.
| Feature | Whole Genome Sequencing (WGS) | Whole Exome Sequencing (WES) |
|---|---|---|
| Genome Coverage | First, WGS reads 100% of 3 billion base pairs (coding + non-coding). | However, WES reads only ~1-2% coding exome regions. |
| Non-Coding Intron Detection | Second, WGS detects deep intronic splice and promoter mutations. | In contrast, WES completely misses non-coding intronic mutations. |
| Structural & CNV Sensitivity | In addition, uniform coverage enables high structural variant sensitivity. | Meanwhile, PCR enrichment biases impair WES CNV detection. |
| Diagnostic Re-analysis Potential | Finally, dataset can be re-analyzed indefinitely as new genes are discovered. | Likewise, limited to previously captured exomic regions. |
Frequently Asked Questions
Is a Whole Genome Sequencing test painful? ▼
However, routine peripheral blood collection involves only a standard needle prick, while genomic sequencing is laboratory-based.
Do I need to fast before Whole Genome Sequencing? ▼
Because genomic DNA extraction depends on cellular DNA rather than blood sugar, fasting is unnecessary.
How long does the sample collection take? ▼
Generally, blood collection takes 5 minutes, while 3 billion base pair bioinformatic sequencing requires 21 to 30 days.
How long until I receive diagnostic results? ▼
Fortunately, detailed ACMG-classified genome reports are delivered within 21 to 30 business days.
What is the cost of Whole Genome Sequencing? ▼
Overall, a high-precision Whole Genome Sequencing test ranges from ₹45,000 to ₹75,000 all-inclusive.
Quick Appointment Booking
Schedule your Whole Genome Sequencing with accredited genomic experts.
Call: 088793 27184 WhatsApp BookingTest Summary
Reporting Clinical Diagnostic Specialist
Dr. Pratibha Patil
Chief Consultant Radiologist & Clinical Diagnostics Specialist
MBBS, MD (Radiodiagnosis) · 15+ Years Clinical Experience
Furthermore, your Whole Genome Sequencing data is evaluated and reported by senior clinical geneticists and bioinformaticians following ACMG guidelines. Consequently, detailed reports provide treating physicians with definitive evidence for patient care.
Our Accreditations & Quality Standards
Certified excellence ensuring NGS sequencing accuracy, 30x coverage depth, and patient privacy.
What Our Patients Say
Real feedback from patients who completed Whole Genome Sequencing with us.
“Whole Genome Sequencing at Henotic Diagnostics finally solved my daughter’s rare genetic disorder after exome testing missed the intronic mutation. Furthermore, the genetic counseling was life-changing.”
– Dr. Manish P.
Verified Patient Review“Smooth blood collection at home. In addition, receiving our raw FASTQ and BAM digital files alongside the ACMG report was fantastic.”
– Swati R.
Verified Patient Review“Transparent pricing and NABL accredited facility. Dr. Pratibha Patil’s team delivers gold standard molecular diagnostic care.”
– Alok T.
Verified Patient ReviewRelevant Diagnostic Genomic & Molecular Services
Corporate Booking Office & Location
If you require a high precision Whole Genome Sequencing test for comprehensive genetic evaluation, do not delay. Call to schedule your sample collection.
Henotic Diagnostics
Second floor, Millennium Empire, Business Park, Plot No 47, D Mart Rd, Sector 15, Kharghar, Navi Mumbai, Panvel, Maharashtra 410210
Phone: 088793 27184 | Hours: Open 24 Hours